FerAppease® Cattle Stress Management

Directions for Use

Use only on healthy dairy and beef cattle.

Adult cattle (Over 200 Pounds)

• Apply 5 mL behind the poll (nuchal skin)
• Apply an additional 5 mL to the skin above the muzzle
• Total dose: 10 mL per animal

Calves and youngstock (Under 200 pounds)

• Apply 2.5 mL behind the poll
• Apply an additional 2.5 mL above the muzzle
• Total dose: 5 mL per animal

For best results, administer approximately 24 hours prior to a stressful event whenever possible. FerAppease begins working shortly after application and can provide benefits for up to 14 days. Shake well before use. Do not inject

Ingredients

Maternal Bovine Appeasing Substance (mBAS) Analogue

• 100 mg/mL mBAS analogue (10%)

FerAppease contains a synthetic analogue of Maternal Bovine Appeasing Substance, a naturally occurring compound that helps create an appeasing effect and reduce threat perception in cattle.

Available Sizes

• 300 mL bottle (Treats approximately 30 adult cattle at labeled dosage.)
• Applicator gun

Storage

• Store at controlled room temperature between 50°F and 86°F (10°C to 30°C)
• Do not refrigerate
• Do not freeze
• Keep container tightly closed when not in use
• Store in a clean, dry location away from direct sunlight

Frequently Asked Questions

What is FerAppease?
FerAppease is a topical cattle stress-management product containing a synthetic analogue of Maternal Bovine Appeasing Substance (mBAS), a naturally occurring compound that helps reduce threat perception and support a calmer response to stressful events.

When should FerAppease be used?
FerAppease can be used anytime cattle are exposed to management or physiological stressors, including weaning, transportation, vaccination, dehorning, castration, branding, breeding, calving, commingling, and dry-off.

How quickly does FerAppease work?
Behavior modulation and stress mitigation begin shortly after application. For best results, apply approximately 24 hours before a planned stressful event. Peak activity occurs from approximately one hour through three days after administration, with benefits that can extend up to 14 days.

What research has been done with FerAppease in beef cattle?
Beef cattle research has shown that FerAppease can improve performance during some of the most stressful points in production, including weaning, transport, feedlot arrival, and processing. Studies have reported improvements in average daily gain, feed efficiency, and overall cattle performance compared to untreated cattle.

Research has also shown reductions in stress-related behaviors and improved adaptability during the receiving period, which can translate into better health outcomes and more consistent performance in the feedlot.

Can FerAppease improve reproductive performance?
Research in dairy cattle has demonstrated improved pregnancy rates when FerAppease was administered at artificial insemination. Studies have also shown improvements in health outcomes during the transition period.

Can FerAppease be used on calves?
Yes. FerAppease can be used on calves and youngstock during stressful events such as weaning, transportation, vaccination, dehorning, and grouping transitions. Dosage should be adjusted according to label directions.

Is there a milk withdrawal or slaughter withdrawal period?
No. When used according to label directions, FerAppease does not require a milk discard period or a pre-slaughter withdrawal interval.

How is FerAppease different from a sedative or tranquilizer?
FerAppease does not sedate cattle. Instead, it works through the animal’s natural behavioral pathways to help reduce threat perception and the physiological stress response while allowing cattle to maintain normal activity and performance.

Is FerAppease only for weaning?
No. While many producers use FerAppease during weaning, it can be beneficial anytime cattle face management or physiological stress, including transportation, breeding, vaccination, dry-off, calving, commingling, and processing events.